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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha : |
27/01/2020 |
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Actualizado : |
27/01/2020 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
ESCRIBANO, C.; SARAVIA, A.; COSTA, M.; CASTELLS, D.; CIAPPESONI, G.; RIET-CORREA, F.; FREIRE, T. |
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Afiliación : |
CECILIA ESCRIBANO, Grupo de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay; INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ANDERSON SARAVIA DE MELO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MONIQUE COSTA, Grupo de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay; DANIEL CASTELLS, Secretariado Uruguayo de Lana, Florida, Uruguay; CARLOS GABRIEL CIAPPESONI SCARONE, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; FRANKLIN RIET-CORREA AMARAL, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; TERESA FREIRE, Grupo de Inmunomodulación y Desarrollo de Vacunas, Departamento de Inmunobiología, Facultad de Medicina, Universidad de La República, Montevideo, Uruguay. |
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Título : |
Resistance to Haemonchus contortus in Corriedale sheep is associated to high parasite-specific IgA titer and a systemic Th2 immune response. |
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Fecha de publicación : |
2019 |
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Fuente / Imprenta : |
Scientific Reports, 1 December 2019, Volume 9, Issue 1, Article number 19579. OPEN ACCESS. Doi: https://doi.org/10.1038/s41598-019-55447-6 |
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ISSN : |
2045-2322 |
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DOI : |
10.1038/s41598-019-55447-6 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received: 21 June 2019 / Accepted: 27 November 2019 / Published: 20 December 2019.
Funding information:
We acknowledge the personnel from Uruguayan Wool Secretariat that assisted with animal studies. This project was funded by INIA (Uruguay) and CSIC-VUSP (Uruguay). C.E. was funded by a scholarship by INIA. |
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Contenido : |
ABSTRACT.
Gastrointestinal nematode infections, including Haemonchus contortus, are one of the main causes of economic losses to ovine farmers worldwide. In order to contribute to the control of nematode infections and avoid parasite spreading we generated divergent resistant and susceptible sheep breeds and evaluated the adaptive immunity of these animals developed upon experimental infection against H. contortus. The selection of resistant or susceptible animals from the Corriedale Breed has been based on Expected Progeny Differences for faecal egg counts per gram. Furthermore, animals from the resistant Corriedale line were inseminated with imported semen from Australian Rylington Merino rams. Thus, the objective of this work was to analyze the adaptive immune response in both susceptible and resistant obtained lambs. Our results indicate that there is a potent parasite-specific local and systemic immune response in resistant animals and that although susceptible lambs can produce high levels of IgA antibodies during the infection, their antibody response is delayed which, together with an impaired specific-Th2 response, does not contribute to initial parasite elimination. Our results shed light into the immune mechanisms that mediate resistance to H. contortus and could constitute important assets to sheep farmers, not only as a means to detect resistance, but also to enhance the efficiency of selection in stud flocks.
© 2019, The Author(s). |
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Palabras claves : |
HAEMONCHUS; SHEEP. |
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Asunto categoría : |
L01 Ganadería |
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URL : |
https://www.nature.com/articles/s41598-019-55447-6.pdf
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Marc : |
LEADER 02635naa a2200253 a 4500
001 1060699
005 2020-01-27
008 2019 bl uuuu u00u1 u #d
022 $a2045-2322
024 7 $a10.1038/s41598-019-55447-6$2DOI
100 1 $aESCRIBANO, C.
245 $aResistance to Haemonchus contortus in Corriedale sheep is associated to high parasite-specific IgA titer and a systemic Th2 immune response.$h[electronic resource]
260 $c2019
500 $aArticle history: Received: 21 June 2019 / Accepted: 27 November 2019 / Published: 20 December 2019. Funding information: We acknowledge the personnel from Uruguayan Wool Secretariat that assisted with animal studies. This project was funded by INIA (Uruguay) and CSIC-VUSP (Uruguay). C.E. was funded by a scholarship by INIA.
520 $aABSTRACT. Gastrointestinal nematode infections, including Haemonchus contortus, are one of the main causes of economic losses to ovine farmers worldwide. In order to contribute to the control of nematode infections and avoid parasite spreading we generated divergent resistant and susceptible sheep breeds and evaluated the adaptive immunity of these animals developed upon experimental infection against H. contortus. The selection of resistant or susceptible animals from the Corriedale Breed has been based on Expected Progeny Differences for faecal egg counts per gram. Furthermore, animals from the resistant Corriedale line were inseminated with imported semen from Australian Rylington Merino rams. Thus, the objective of this work was to analyze the adaptive immune response in both susceptible and resistant obtained lambs. Our results indicate that there is a potent parasite-specific local and systemic immune response in resistant animals and that although susceptible lambs can produce high levels of IgA antibodies during the infection, their antibody response is delayed which, together with an impaired specific-Th2 response, does not contribute to initial parasite elimination. Our results shed light into the immune mechanisms that mediate resistance to H. contortus and could constitute important assets to sheep farmers, not only as a means to detect resistance, but also to enhance the efficiency of selection in stud flocks. © 2019, The Author(s).
653 $aHAEMONCHUS
653 $aSHEEP
700 1 $aSARAVIA, A.
700 1 $aCOSTA, M.
700 1 $aCASTELLS, D.
700 1 $aCIAPPESONI, G.
700 1 $aRIET-CORREA, F.
700 1 $aFREIRE, T.
773 $tScientific Reports, 1 December 2019, Volume 9, Issue 1, Article number 19579. OPEN ACCESS. Doi: https://doi.org/10.1038/s41598-019-55447-6
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Registro original : |
INIA Las Brujas (LB) |
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| Registros recuperados : 110 | |
| 81. |  | PÉREZ, N.; NIELL, S.; JESÚS, F.; PÉREZ, C.; CARRASCO-LETELIER, L.; MENDOZA, Y.; DÍAZ-CETTI, S. Caracterización acústica de la colmena para la detección temprana de contaminación por agroquímicos: nota técnica. Cangüé, 2. época, n. 35, p. 2-6, 2014.| Tipo: Artículos en Revistas Agropecuarias |
| Biblioteca(s): INIA La Estanzuela. |
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| 85. | | RESQUÍN, F.; BENTANCOR, L.; CARRASCO-LETELIER, L.; RACHID, C.; NAVARRO-CERRILLO, R.M. Rotation length of intensive Eucalyptus plantations: how it impacts on productive and energy sustainability. Biomass and Bioenergy, 2022, Volume 166, article 106607. doi: https://doi.org/10.1016/j.biombioe.2022.106607 Article history: Received 11 April 2022; Received in revised form 31 August 2022; Accepted 18 September 2022; To be published November 2022.
Corresponding author: Fernando Resquin, Route 5 km 368, CP45000, INIA Tacuarembó, Uruguay. E-mail...| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA Las Brujas. |
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| 88. | | RESQUÍN, F.; DUQUE-LAZO, J.; ACOSTA-MUÑÓZ, C.; RACHID, C.; CARRASCO-LETELIER, L.; NAVARRO-CERRILLO, R.M. Modelling Current and Future Potential Habitats for Plantations of Eucalyptus grandis Hill ex Maiden and E. dunnii Maiden in Uruguay. Forests, 2020, vol. 11, Issue 9, Article 948. OPEN ACCESS. Doi: https://doi.org/10.3390/f11090948 Article history: Received: 6 July 2020; Accepted: 24 August 2020; Published: 29 August 2020.
Supplementary material.
This article belongs to the Special Issue Modeling of Species Distribution and Biodiversity in Forests -...| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA Las Brujas; INIA Tacuarembó. |
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| 89. | | RESQUÍN, F.; FARIÑA, I.; RACHID, C.; RAVA, A.; DOLDÁN, J.; HIRIGOYEN, A.; INDERKUM, F.; ALEN, S.; OLMOS, V.M.; CARRASCO-LETELIER, L. Impact of rotation length of Eucalyptus globulus Labill. on wood production, kraft pulping, and forest value. IForest, 2022, volume 15, issue 1, pp. 433-443. OPEN ACCESS. doi: https://doi.org/10.3832/ifor4040-015 Article history: Received December 17 2021; Accepted August 08 2022; Published online October 2022. -- Corresponding author: Resquin, F.; Programa Nacional de Investigación Forestal, INIA-Instituto Nacional de Investigación Agropecuaria,...| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA Las Brujas. |
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| 96. | | RESQUÍN, F.; RACHID, C.; HIRIGOYEN, A.; DOLDÁN, J.; LOPRETTI, M.; BONIFACINO, S.; BUXEDAS, L.; VÁZQUEZ, S.; SAPOLINSKI, A.; GONZÁLEZ, M.; CARRASCO-LETELIER, L.; CAPDEVIELLE, F. Producción de biomasa y etanol a partir de Eucalyptus en plantaciones de alta densidad. Revista INIA Uruguay, 2015, n. 41, p. 35-38 (Revista INIA; 41)| Tipo: Artículos en Revistas Agropecuarias |
| Biblioteca(s): INIA La Estanzuela; INIA Tacuarembó. |
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| 97. | | RESQUÍN, F.; RACHID, C.; HIRIGOYEN, A.; SCOZ, R.; DOLDAN, J.; LOPRETTI, M.; CAPDEVIELLE, F.; CARRASCO-LETELIER, L.; DE MARTINI, M.L. Avances en la evaluación de plantaciones forestales para producción de energía. Revista INIA Uruguay, 2014, no. 36, p. 41-45 (Revista INIA; 36)| Tipo: Artículos en Revistas Agropecuarias |
| Biblioteca(s): INIA La Estanzuela; INIA Tacuarembó. |
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| 98. | | RÍOS, M.; ZALDÚA, N.; CARRASCO-LETELIER, L.; HARRIET, J.; PEDRETTI, R.; BAETEN, G.; NIETO, J.; STEINHARDT, M.; POSSE, S.; MAIDANA, R.; IVANCHENKO, J.; CÁCERES, M.; ROSANO, Á. Evaluación participativa de niveles de plaguicidas en la producción apícola en la cuenca del sitio RAMSAR. In: RÍOS, M ZALDÚA N. CUPEIRO, S. (Ed.). Evaluación participativa de plaguicidas en el sitio RAMSAR, Parque Nacional Esteros de Farrapos e Islas del Río Uruguay. Montevideo, UY: Vida Silvestre, 2010. p. 41-58.| Tipo: Capítulo en Libro Técnico-Científico |
| Biblioteca(s): INIA La Estanzuela. |
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| Registros recuperados : 110 | |
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